diff --git a/install/linux/dangerzone.spec b/install/linux/dangerzone.spec
index 8f9429a..2c436b9 100644
--- a/install/linux/dangerzone.spec
+++ b/install/linux/dangerzone.spec
@@ -50,6 +50,19 @@ URL:            https://dangerzone.rocks
 #     https://docs.fedoraproject.org/en-US/packaging-guidelines/SourceURL/#_troublesome_urls
 Source0:        https://github.com/freedomofpress/dangerzone/archive/refs/tags/v%{version}.tar.gz#/dangerzone-%{version}.tar.gz
 
+################################################################################
+# Package Replacements
+
+%if 0%{?_qubes}
+# Users who install Dangerzone with native Qubes support must uninstall
+# Dangerzone with container support.
+Conflicts:      dangerzone
+%else
+# Users who install Dangerzone with container support must uninstall Dangerzone
+# with native Qubes support.
+Conflicts:      dangerzone-qubes
+%endif
+
 ################################################################################
 # Package Requirements